Molecular Formula | C26H44NNaO7S |
Molar Mass | 537.69 |
Melting Point | 120-125oC |
Water Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
Appearance | Shape Solid Color White to Pale Beige |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Stability | Hygroscopic |
Use | Tauro-β-muricholic Acid sodium (T-βMCA sodium) is an endogenous metabolite, a competitive and reversible FXR antagonist, with an IC50 value of 40 μM. |
T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC 50 ~10 μM).
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells.
T-βMCA sodium induces proliferation and DNA damage in Lgr5 cells.
IC50: 40 μM (FXR)